49ers vs. Cardinals, Seahawks vs. Giants pick: NFL Week 5 odds, predictions

Football handicapper Sean Treppedi is in his first season in The Post’s NFL Bettor’s Guide. With the fickle week-to-week results of the NFL, each matchup should be considered in a vacuum — and when it comes to the Giants, their win against Cleveland followed by the valiant loss to Dallas shouldn’t be overvalued. Seattle is making a steadfast case for the NFC West.It’s the No.

4 overall team in DVOA facing the No.25 ranked Giants.

Geno Smith is commanding an explosive cast of weapons with a 72.3 completion percentage while accruing the most passing yards and first downs.The only bright spot in blue is Malik Nabers, and he suffered a concussion last week. We can still be reassured by what Arizona’s offense is capable of despite the blowout loss to Washington.Kyler Murray is neck-and-neck with Brock Purdy in passer rating at 104.6 and 104.9, respectively, all while James Conner spearheads the ground game at 5.3 yards per carry.

Besides, underdogs by four-plus points that lost by 28-plus points in the prior week have covered at a 62 percent rate in the past 20 years. San Francisco may have righted the ship against a monotonous New England team last week, but it remains plagued by injuries — which include George Kittle, Fred Warner and, of course, Christian McCaffrey.Though Purdy has had success against Arizona, he’s 9-12 ATS when favored by four points or more. Las week: 1-1.

Vikings (W).Titans-Dolphins Under (L) Season: 5-3....