Wellness trends for the extreme (and extremely rich): From $10k-per-session IVs to frog venom

The biggest room in the world is the room for improvement, right?And as biohacking techniques like cold showers and intermittent fasting go mainstream, New York City’s most dedicated wellness seekers are venturing into more extreme territory.Take, for instance, kambo — poison from Amazonian tree frogs that has become a favorite way for some in Silicon Valley to detox both emotionally and physically.A patient’s skin is singed to create a small wound where the kambo is applied.“It’s pretty wild — your face swells up like a frog and then you throw up, and you’re supposed to purge all the toxins that are in your body,” said Lauren Berlingeri, the co-founder of HigherDose, a New York-based wellness technology company that sells popular products for at-home use like red-light therapy masks and sauna blankets.Kambo treatments are known to give users diarrhea and heart palpitations, but fans claim that it can cure everything from anxiety to migraines if you’re willing to deal with some hours of pain.

Berlingeri — who took part in a kambo ceremony and “20 minutes of flu-like purging” for an episode of her “BiohackHERS” podcast — said the most dedicated fans will travel to Peru where the most expert practitioners administer the treatment for around $150.Then there’s ozone insufflation therapy — said to be a favorite of Gwyneth Paltrow, naturally — which blows ozone up the rectum with the promise of healing the gut and killing bacteria.

Getting the treatment professionally done at places like Next Health in NYC costs about $150 a session.But, for $1,850 you can get an at-home starter kit from biohackersupply.com.

Note that the FDA has warned that ingesting ozone can be dangerous.For those looking to slow aging, total plasma exchange (TPE) filters plasma to remove unhealthy particles — like autoantibodies that attack healthy cells — to reduce inflammation and strengthen immunity.Multimillionaire venture capitalist turned controversi...